Other adverse effects

To manage symptoms for which the causal link with depot medroxyprogesterone is uncertain (eg headaches, mood changes, breast tenderness, loss of libido) consider whether other factors such as life circumstances could be the cause, particularly if they develop after the first 3 months of use. If troublesome symptoms persist, consider an alternative method of contraception.

An association between first prescription of an antidepressant and use of hormonal contraception has been seen, but a causal link is not proven. Advise users to report new or worsening mood-related symptoms.