Combination therapy for premature ejaculation

Combination therapy with a phosphodiesterase type 5 (PDE5) inhibitor and selective serotonin reuptake inhibitor (SSRI) has been reported to be more effective than SSRI therapy alone, but has a higher rate of adverse effects.

If symptoms do not respond to SSRI monotherapy, suitable regimens for combination therapy (to be taken no more frequently than once every 24 hours) are:

1 sildenafil 50 mg orally, taken 1 hour before sexual activity premature ejaculation, combination therapy sildenafil

PLUS EITHER

1 dapoxetine 30 mg orally, taken 1 hour before sexual activity premature ejaculation, combination therapy dapoxetine

OR

1 paroxetine 10 to 20 mg orally, daily premature ejaculation, combination therapy paroxetine

OR

1 tadalafil 20 mg orally, taken 2 hours before sexual activity premature ejaculation, combination therapy tadalafil

PLUS

paroxetine  20 mg orally, taken 2 hours before sexual activity. paroxetine