Key references: Nonhormonal drug therapy for vasomotor symptoms of menopause

Cancer Australia. Management of menopausal symptoms in women with a history of breast cancer Clinical practice guidelines. Surry Hills NSW: Cancer Australia; 2016. https://canceraustralia.gov.au/publications-and-resources/clinical-practice-guidelines/menopausal-guidelines/clinical-practice-recommendations-and-practice-points#_RECPP_31
Nonhormonal management of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Menopause; quiz 73-4. 2015 22(11):1155–72 quiz 1173-1174. https://www.ncbi.nlm.nih.gov/pubmed/26382310
Johns C, Seav SM, Dominick SA, Gorman JR, Li H, Natarajan L, et al. Informing hot flash treatment decisions for breast cancer survivors: a systematic review of randomized trials comparing active interventions. Breast Cancer Res Treat 2016;156(3):415–26. https://www.ncbi.nlm.nih.gov/pubmed/27015968
Leon-Ferre RA, Novotny PJ, Wolfe EG, Faubion SS, Ruddy KJ, Flora D, et al. Oxybutynin vs placebo for hot flashes in women with or without breast cancer: a randomized, double-blind clinical trial (ACCRU SC-1603). JNCI Cancer Spectr 2020;4(1):pkz088. https://www.ncbi.nlm.nih.gov/pubmed/32337497
Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, et al. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA 2006;295(17):2057–71. https://www.ncbi.nlm.nih.gov/pubmed/16670414
Pinkerton JV. Hormone therapy for postmenopausal women. N Engl J Med 2020;382(5):446–55. https://www.ncbi.nlm.nih.gov/pubmed/31995690
Pinkerton JV, Santen RJ. Managing vasomotor symptoms in women after cancer. Climacteric 2019;22(6):544–52. https://www.ncbi.nlm.nih.gov/pubmed/31081391
Rada G, Capurro D, Pantoja T, Corbalan J, Moreno G, Letelier LM, et al. Non-hormonal interventions for hot flushes in women with a history of breast cancer. Cochrane Database Syst Rev 2010;(9):CD004923. https://www.ncbi.nlm.nih.gov/pubmed/20824841
Shan D, Zou L, Liu X, Shen Y, Cai Y, Zhang J. Efficacy and safety of gabapentin and pregabalin in patients with vasomotor symptoms: a systematic review and meta-analysis. Am J Obstet Gynecol 2020;222(6):564–79 e12. https://www.ncbi.nlm.nih.gov/pubmed/31870736
Stubbs C, Mattingly L, Crawford SA, Wickersham EA, Brockhaus JL, McCarthy LH. Do SSRIs and SNRIs reduce the frequency and/or severity of hot flashes in menopausal women. J Okla State Med Assoc 2017;110(5):272–4. https://www.ncbi.nlm.nih.gov/pubmed/28649145
The Women's. Treating hot flushes: an alternative to hormonal replacement therapy [Fact sheet]. Parkville: The Royal Women's Hospital; 2010. https://www.thewomens.org.au/health-information/fact-sheets/#t