Management overview for colchicine poisoning from plants

Note: Urgently contact a clinical toxicologist or poisons information centre if colchicine poisoning from plants is suspected.

Plants that contain colchicine include autumn crocus (Colchicum autumnale) and glory lily (Gloriosa superba) (see Common plant-derived toxins for common plant-derived toxins). Accidental exposure to autumn crocus has occurred when it is mistaken for other edible plants, such as wild garlic (Allium ursinium).

Colchicine is a highly cytotoxic alkaloid that inhibits mitosis of dividing cells. Poisoning from colchicine-containing plants causes similar toxicity as poisoning from colchicine tablets, and is potentially lethal.

If colchicine poisoning from plants is suspected, urgently contact a clinical toxicologist or poisons information centre (13 11 26). Management is time critical and treatment options are limited. Early gastrointestinal decontamination with activated charcoal and supportive care are of primary importance. All patients who present with deliberate self-poisoning from plants require psychiatric assessment before discharge.