Pyridoxine or thiamine supplementation for ethylene glycol poisoning
Pyridoxine or thiamine supplements are recommended for ethylene glycol poisoning because they are cofactors in the metabolism of glyoxylic acid, a toxic acid metabolite of ethylene glycol, to nontoxic metabolites. For adults and children, use:
1pyridoxine 50 mg intravenously, every 6 hours for 2 days1 toxic alcohol poisoning - methanol and ethylene glycol
OR
1 thiamine 100 mg intravenously, every 6 hours for 2 days. toxic alcohol poisoning - methanol and ethylene glycol
1 Intravenous pyridoxine is
not registered for use in Australia but is available via the Special Access Scheme (SAS).
Pharmacists or emergency staff should check the emergency and life-saving drugs
register for their state. This register lists hospitals that hold specific SAS drugs
that may be borrowed in an emergency. Most hospitals have a limited supply of 50
mg/mL pyridoxine vials.Return