Observation and patient disposition after sodium valproate poisoning

The minimum period of medical observation for sodium valproate poisoning varies depending on symptoms and the dose ingested:

• more than 500 mg/kg—observe for at least 12 hours after ingestion
• more than 200 mg/kg—observe for at least 8 hours after ingestion.

Discharge patients when they are alert, ambulant and clinically stable.

Drug-naive children who have accidentally ingested less than 200 mg/kg of sodium valproate can be discharged if they are asymptomatic and can be supervised in a safe environment.

Sedative drugs can continue to cause significant cognitive impairment for several days following exposure. Advise patients not to drive or operate machinery for at least 3 days after discharge.