Toxic dose

Antipsychotic drug poisoning can have significant effects in children and other people who are treatment-naive to antipsychotic drugs—sedation and hypotension can occur even at therapeutic doses.

Antipsychotic drug doses that have the potential to cause toxicity in drug-naive children are given in Potential toxic doses of some antipsychotic drugs in drug-naive children; drug-naive children who have taken a potentially toxic dose require medical assessment and observation in hospital.

Table 1. Potential toxic doses of some antipsychotic drugs in drug-naive children
[NB1]
Antipsychotic drug	Potential toxic dose in drug-naive children
amisulpride	any dose
aripiprazole	more than 1 mg/kg
asenapine	more than 20 mg
chlorpromazine	more than 2 mg/kg
clozapine	more than 2.5 mg/kg
haloperidol	more than 0.15 mg/kg
lurasidone	more than 80 mg
olanzapine	more than 0.4 mg/kg
paliperidone	more than 12 mg
quetiapine	more than 25 mg
risperidone	more than 1 mg
ziprasidone	more than 80 mg
Note: NB1: For the potential toxic dose of other antipsychotic drugs in drug-naive children, seek advice from a clinical toxicologist or poisons information centre (13 11 26).