Management overview for baclofen poisoning

Baclofen is a gamma-aminobutyric acid (GABA) analogue that acts as a GABA_B-receptor agonist. It is used to treat muscle spasticity and, more recently, alcohol dependence and gamma-hydroxybutyrate (GHB) withdrawal. Baclofen poisoning is becoming more common, reflecting its increased prescribing and use in the community.

After large ingestions, baclofen causes coma, seizures, prolonged delirium and respiratory depression.

Most cases of baclofen poisoning are managed with supportive care. Patients with coma and respiratory depression may require intubation and ventilation. With supportive care in an intensive care unit, most patients recover within 72 hours if they have not developed hypoxic encephalopathy.