Clinical presentation

Bupropion poisoning is characterised by severe agitation and aggression, and a significant risk of seizures, which can be delayed up to 24 hours after ingestion.

Effects of bupropion poisoning include:

• gastrointestinal effects—nausea, vomiting
• central nervous system (CNS) effects—agitation, aggression, seizures, hallucinations, tremor
• cardiovascular effects
  • hypertension and sinus tachycardia (common)
  • hypotension, QRS widening and arrhythmias after ingestions of more than 9 g of bupropion.