Key references: Pregabalin and gabapentin poisonings

  • Cairns R, Schaffer AL, Ryan N, Pearson SA, Buckley NA. Rising pregabalin use and misuse in Australia: trends in utilization and intentional poisonings. Addiction 2019;114(6):1026–34. https://www.ncbi.nlm.nih.gov/pubmed/30098227
  • Daly C, Griffin E, Ashcroft DM, Webb RT, Perry IJ, Arensman E. Intentional drug overdose involving pregabalin and gabapentin: Findings from the National Self-Harm Registry Ireland, 2007–2015. Clin Drug Investig 2018;38(4):373–80. https://www.ncbi.nlm.nih.gov/pubmed/29264838
  • Dassanayake TL, Jones AL, Michie PT, Carter GL, McElduff P, Stokes BJ, et al. Risk of road traffic accidents in patients discharged following treatment for psychotropic drug overdose: a self-controlled case series study in Australia. CNS Drugs 2012;26(3):269–76. https://www.ncbi.nlm.nih.gov/pubmed/22329565
  • Dassanayake TL, Michie PT, Jones AL, Mallard T, Whyte IM, Carter GL. Cognitive skills underlying driving in patients discharged following self-poisoning with central nervous system depressant drugs. Traffic Inj Prev 2012;13(5):450–7. https://www.ncbi.nlm.nih.gov/pubmed/22931174
  • Klein-Schwartz W, Shepherd JG, Gorman S, Dahl B. Characterization of gabapentin overdose using a poison center case series. J Toxicol Clin Toxicol 2003;41(1):11–5. https://www.ncbi.nlm.nih.gov/pubmed/12645962
  • Miller A, Price G. Gabapentin toxicity in renal failure: the importance of dose adjustment. Pain Med 2009;10(1):190–2. https://www.ncbi.nlm.nih.gov/pubmed/18721173
  • Spiller HA, Bratcher R, Griffith JR. Pregabalin overdose with benign outcome. Clin Toxicol (Phila) 2008;46(9):917. https://www.ncbi.nlm.nih.gov/pubmed/18668385
  • Stewart BH, Kugler AR, Thompson PR, Bockbrader HN. A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma. Pharm Res 1993;10(2):276–81. https://www.ncbi.nlm.nih.gov/pubmed/8456077
  • Verma A, St Clair EW, Radtke RA. A case of sustained massive gabapentin overdose without serious side effects. Ther Drug Monit 1999;21(6):615–7. https://www.ncbi.nlm.nih.gov/pubmed/10604821
  • Wood DM, Berry DJ, Glover G, Eastwood J, Dargan PI. Significant pregabalin toxicity managed with supportive care alone. J Med Toxicol 2010;6(4):435–7. https://www.ncbi.nlm.nih.gov/pubmed/20373065