Pharmacological therapies

Pentoxifylline (oxpentifylline) may be considered as an adjunctive therapy for patients with ulcers that have not healed despite optimal therapy, with specialist advice. Pentoxifylline (o xpentifylline) is not registered by the Australian Therapeutic Goods Administration (TGA) for treatment of venous leg ulcers. It has significant precautions and drug interactions.

Good-quality evidence to support the use of micronised purified flavonoid fraction (MPFF) for venous leg ulcers is lacking, and this product is not readily available in Australia.

Low-dose aspirin has not been shown to improve healing of venous leg ulcers.