Differential diagnosis of altitude illness

In people who are unwell at high altitude, consider differential diagnoses for altitude illness as well as comorbidities that may be aggravated (eg by hypoxia, by exertion if hiking); see Differential diagnoses in acute mountain sickness (AMS) and high-altitude cerebral oedema (HACE) and Differential diagnoses in high-altitude pulmonary oedema (HAPE).

Figure 1. Differential diagnoses in acute mountain sickness (AMS) and high-altitude cerebral oedema (HACE)

Luks, 2017

Figure 2. Differential diagnoses in high-altitude pulmonary oedema (HAPE)
  • respiratory infection, such as pneumonia, acute bronchitis, SARS (eg COVID-19)
  • pulmonary embolus
  • heart failure
  • acute coronary syndrome
  • asthma
  • exertional hyponatraemia
Note:

SARS = syndrome of acute respiratory distress; COVID-19 = coronavirus disease of 2019