Intravenous therapy for H. influenzae bronchiectasis exacerbations in adults

For adults with a bronchiectasis exacerbation who require intravenous therapy, if H. influenzae is isolated in the sputum sample and is susceptible to amoxicillin or ampicillin, use:

1amoxicillin 1 g intravenously, 6-hourly; see advice on modification and duration of therapy. For dosage adjustment in adults with kidney impairment, see amoxicillin dosage adjustment amoxicillin amoxicillin amoxicillin

1ampicillin 1 g intravenously, 6-hourly; see advice on modification and duration of therapy. For dosage adjustment in adults with kidney impairment, see ampicillin dosage adjustment. ampicillin ampicillin ampicillin

If the H. influenzae isolate is resistant to amoxicillin or ampicillin (ie beta-lactamase–producing), or if the results of susceptibility testing are not available, use:

ceftriaxone 1 g intravenously, daily; see advice on modification and duration of therapy. ceftriaxone ceftriaxone ceftriaxone

For adults who have had a nonsevere (immediate or delayed) or a severe immediate¹ hypersensitivity reaction to a penicillin, use ceftriaxone at the dosage above.

For adults who have had a severe delayed² hypersensitivity reaction to a penicillin, use:

moxifloxacin 400 mg intravenously, daily; see advice on modification and duration of therapy. For dosage adjustment in adults with kidney impairment, see moxifloxacin dosage adjustment. moxifloxacin moxifloxacin moxifloxacin

¹ Severe immediate hypersensitivity reactions include anaphylaxis, compromised airway, airway angioedema, hypotension and collapse.Return

² Severe delayed hypersensitivity reactions include cutaneous adverse drug reactions (eg drug rash with eosinophilia and systemic symptoms [DRESS], Stevens–Johnson syndrome/toxic epidermal necrolysis [SJS/TEN], severe blistering or desquamative rash), and significant internal organ involvement (eg acute interstitial nephritis).Return