Oral therapy for H. influenzae bronchiectasis exacerbations in adults

If H. influenzae is isolated in the sputum sample of an adult with a bronchiectasis exacerbation and the isolate is susceptible to amoxicillin, useChang, 2023:

amoxicillin 1 g orally, 8-hourly; see advice on modification and duration of therapy. For dosage adjustment in adults with kidney impairment, see amoxicillin dosage adjustment. amoxicillin amoxicillin amoxicillin

If the H. influenzae isolate is resistant to amoxicillin (ie beta-lactamase–producing), or if the results of susceptibility testing are not available, useChang, 2023 Hill, 2019:

amoxicillin+clavulanate 875+125 mg orally, 12-hourly; see advice on modification and duration of therapy. For dosage adjustment in adults with kidney impairment, see amoxicillin+clavulanate oral dosage adjustment. amoxicillin + clavulanate amoxicillin+clavulanate amoxicillin+clavulanate

For adults who have had a hypersensitivity reaction to a penicillin, use:

doxycycline 100 mg orally, 12-hourly; see advice on modification and duration of therapy. doxycycline doxycycline doxycycline