Cryptococcosis consolidation therapy

For cryptococcosis consolidation therapy in adults and children requiring 3-phase antifungal therapy, useChang 2021:

fluconazole 400 to 800 mg (child: 12 mg/kg up to 800 mg) orally, daily, for 8 weeks. For dosage adjustment in adults with kidney impairment, see fluconazole dosage adjustment. fluconazole fluconazole fluconazole

In most adults, fluconazole at the lower end of the range (400 mg) is suitable for cryptococcosis consolidation therapy. Higher doses may be required:

for heavier patients (eg BMI 30 kg/m² or more)
when the fluconazole minimum inhibitory concentration (MIC) is elevated (eg 8 mg/L)
when induction therapy cannot be completed.

Consider therapeutic drug monitoring if the higher fluconazole dose (800 mg) is used. Fluconazole can cause nausea at higher doses.