Standard regimen for prosthetic valve endocarditis
For adults and children with prosthetic valve endocarditis caused by viridans streptococci or S. bovis group with penicillin MIC greater than 0.125 mg/L and less than or equal to 0.5 mg/L, use:
benzylpenicillin 1.8 g (child: 50 mg/kg up to 1.8 g) intravenously, 4-hourly for 6 weeks. For dosage adjustment in adults with kidney impairment, see benzylpenicillin dosage adjustment benzylpenicillin benzylpenicillin benzylpenicillin
PLUS
gentamicin (adult and child) 1 mg/kg intravenously, 8-hourly for 2 weeks (monitor plasma concentration; see Principles of aminoglycoside use)1. gentamicin gentamicin gentamicin
1 For adults with obesity (body mass index 30 kg/m2 or more), use lean body weight to calculate the dose. For children with obesity, use adjusted body weight to calculate the dose.Return