Standard regimen for native valve endocarditis

For adults and children with native valve endocarditis caused by viridans streptococci or S. bovis group with penicillin MIC greater than 0.5 mg/L and less than or equal to 2 mg/L, use:

benzylpenicillin 1.8 g (child: 50 mg/kg up to 1.8 g) intravenously, 4-hourly for 4 weeks. For dosage adjustment in adults with kidney impairment, see benzylpenicillin dosage adjustment benzylpenicillin benzylpenicillin benzylpenicillin

PLUS

gentamicin (adult and child) 1 mg/kg intravenously, 8-hourly for 4 weeks (monitor plasma concentration; see Principles of aminoglycoside use)¹. gentamicin gentamicin gentamicin

Patients with complicated infection may require a 6-week course.

¹ For adults with obesity (body mass index 30 kg/m² or more), use lean body weight to calculate the dose. For children with obesity, use adjusted body weight to calculate the dose.Return