Clinical history for initial assessment of adults reporting trimethoprim+sulfamethoxazole hypersensitivity

Clinical history is critically important in the diagnosis of trimethoprim+sulfamethoxazole hypersensitivity. Information about obtaining an accurate hypersensitivity history can be found in Clinical history for initial assessment of patients reporting antimicrobial hypersensitivity.

The SULF-FAST tool (which was derived from PEN-FAST Penicillin allergy decision rule) may be used to assess risk in patients reporting trimethoprim+sulfamethoxazole hypersensitivity; however, it requires further validation.Waldron, 2023