Management for cutaneous features of Behçet syndrome
Cutaneous features of Behçet syndrome are often managed in conjunction with a dermatologist. The usual approach is to start colchicine for mild features or prevention of cutaneous lesionsHatemi, 2018. If colchicine is indicated for cutaneous lesions in Behçet syndrome, use:
colchicine 500 micrograms orally, once or twice daily. colchicine colchicine colchicine
Reduce colchicine dosage in people with kidney impairment. Patients taking colchicine long term should have monitoring of their full blood count and kidney function and be made aware of signs associated with colchicine toxicity (see Colchicine poisoning for further advice). Consider low-dose systemic corticosteroids for lesions refractory to colchicine. Acneiform and papulopustular lesions are usually managed in the same way as acneHatemi, 2018; see management for Acne in the Dermatology guideline.
People with erythema nodosum and pyoderma gangrenosum usually require higher doses of systemic corticosteroids, or immunomodulatory therapy with azathioprine.