Nonsteroidal anti-inflammatory drugs for primary dysmenorrhoea
NSAIDs relieve primary dysmenorrhoea by suppressing prostaglandins in menstrual fluid. Evidence is insufficient to favour one NSAID over another. In individuals at risk of gastrointestinal adverse effects from NSAIDs (see NSAID-induced ulcers), a proton pump inhibitor may be prescribed concurrently. Suitable NSAID regimens (which start ideally 48 hours before expected onset of menstruation or with onset of pain) include:
1 ibuprofen 200 to 400 mg orally, 3 times daily. Continue for first 48 to 72 hours of menstruation primary dysmenorrhoea ibuprofen
OR
1 mefenamic acid 500 mg orally, 3 times daily. Continue for first 48 to 72 hours of menstruation1 primary dysmenorrhoea mefenamic acid
OR
1 naproxen 500 mg orally initially, then 250 mg every 6 to 8 hours. Continue for first 48 to 72 hours of menstruation. primary dysmenorrhoea naproxen