Immediate immune-mediated (non-IgE) hypersensitivity reactions to acetylcysteine

Acetylcysteine is generally well tolerated, but occasionally immediate immune-mediated (non-IgE) hypersensitivity reactions can occur—reactions include rash, urticaria, flushing, and (rarely) bronchospasm and hypotension. If symptoms occur, stop the infusion, treat the reaction as required with antihistamines and bronchodilators, and restart the infusion when the reaction subsides. This reaction does not indicate an allergy or contraindicate further treatment with acetylcysteine.

See also Anaphylaxis for management of immediate immune-mediated (non-IgE) hypersensitivity reactions.