Toxic dose

Risk assessment for unintentional paracetamol poisoning (also referred to as repeated supratherapeutic ingestion [RSTI]) is based on:

• the dose of paracetamol ingested each day
• the patient’s symptoms and signs.

Investigate patients who have ingested the following doses of paracetamol:

• 10 g (or 200 mg/kg in patients under 50 kg) or more taken over a 24-hour period
• 12 g (or 300 mg/kg in patients under 40 kg) or more taken over a 48-hour period
• a therapeutic dose (60 mg/kg up to 4 g daily) taken over a 48-hour period if the patient has symptoms of acute liver injury (eg abdominal pain, nausea, vomiting).