Clinical presentation

Effects of pregabalin or gabapentin poisoning usually develop within 1 to 2 hours of ingestion and generally resolve within 12 hours. Both drugs are renally excreted, so kidney impairment can prolong toxicity.

Effects of pregabalin poisoning include:

• central nervous system (CNS) effects
  • CNS depression (altered conscious state ranging from drowsiness to coma); coma has been reported in severe poisonings and co-ingestion with other sedative drugs
  • dizziness, ataxia, tremor, myoclonus, seizures.

Effects of gabapentin poisoning include:

• CNS effects—drowsiness, lethargy, ataxia, dizziness
• gastrointestinal effects—nausea, vomiting.