Key references: Step 4 therapy for asthma in adults and adolescents

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  • Kim LHY, Saleh C, Whalen-Browne A, O'Byrne PM, Chu DK. Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis. Jama 2021;325(24):2466-79. https://www.ncbi.nlm.nih.gov/pubmed/34009257
  • Rodrigo GJ, Neffen H. Efficacy and safety of tiotropium in school-age children with moderate-to-severe symptomatic asthma: a systematic review. Pediatr Allergy Immunol 2017;28(6):573–8. https://www.ncbi.nlm.nih.gov/pubmed/28692145
  • Sobieraj DM, Baker WL, Nguyen E, Weeda ER, Coleman CI, White CM, et al. Association of inhaled corticosteroids and long-acting muscarinic antagonists with asthma control in patients with uncontrolled, persistent asthma: a systematic review and meta-analysis. JAMA 2018;319(14):1473–84. https://www.ncbi.nlm.nih.gov/pubmed/29554174
  • Sobieraj DM, Weeda ER, Nguyen E, Coleman CI, White CM, Lazarus SC, et al. Association of inhaled corticosteroids and long-acting beta-agonists as controller and quick relief therapy with exacerbations and symptom control in persistent asthma: a systematic review and meta-analysis. JAMA 2018;319(14):1485–96. https://www.ncbi.nlm.nih.gov/pubmed/29554195