Overview of granulomatosis with polyangiitis

Granulomatosis with polyangiitis (GPA; formerly known as Wegener granulomatosis) is one of the 3 ANCA-associated vasculitides. It predominantly affects small- to medium-sized blood vessels and typically occurs in middle-aged adults. It is a multisystem disease characterised by necrosis, granuloma formation and vasculitis of the ear, nose and throat, and lower respiratory tract.

All people with granulomatosis with polyangiitis require specialist management. Seek urgent specialist advice if there is a high index of suspicion for granulomatosis with polyangiitis, to determine if immediate treatment is required.