Clinical presentation

Effects of quetiapine poisoning usually develop within 6 hours of ingesting an immediate-release preparation, but can develop up to 12 hours after ingesting a modified-release preparation. Effects include:

• central nervous system (CNS) effects—CNS depression (altered conscious state ranging from drowsiness to coma), dose-dependent respiratory depression, seizures
• cardiovascular effects—tachycardia, hypotension; QT-interval prolongation has been reported, but only at increased heart rates and without torsades de pointes
• anticholinergic effects—in particular delirium and urinary retention (see Anticholinergic toxidrome for management).